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KMID : 0378019890320040089
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New Medical Journal
1989 Volume.32 No. 4 p.89 ~ p.94
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Clinical effects of bromazepam(Lectopam^(®)) on the paychoneurotic symptoms associated with various cardisc diseases
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Abstract
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It is well known that in essential. hypertension, coronary artery disease, cardiac arrhythmi and sudden death psychosocial stress can play some causative roles, and many psychoneuro c symptoms of anxiety, depression,: and somatization are frequently associated with them. These stress-related cardiovascular diseases particularly essential hypertension and coronary arte disease have been the diseases of special interest to behavioral scientists.
Relaxation introduced into clinical practice as a selfregulation method of stress proved effective in treating mild to moderate essential hypertension and reducing the risk of coronary ante disease. However, the efficacy of sedative drugs and vocational change as the other modaliti of stress regulation are still not proven ;besides, study on it has seldom been tried.
Present study was performed to evaluate the clinical effects of bromazepam(Lectopam), a derivative of benzodiazepine, on various psychoneurotic symptoms associated with 35 cardiovascular patients (14 male, 21 female), of whom 28(80%) were essential hypertension, 3 arrhythmia, 2 cardiac neurosis, 1 dilated cardiomyopathy, and 1 coronary artery disease.
The most frequently associated psychoneurotic symptom was headache(21 cases),. and t e other symptoms were palpitation (16 cases), dizziness (14 cases), dyspnea (11 cases), chest .. (4 cases), and insomnia(2 cases). Bromazepam of 2-6 mg /day very effectively relieved - dache(84.6%) and insomnia(100%), and to lesser extent palpitation (62.5%), (dizziness(500,), dyspnea (36.4%) , and chest pain (25%) resulting in overall efficacy rate of 63% (43 / 73 cast´). Side effects of bromazepam were noted in 7 patients(20%), but too trivial to gain a media - concern. Clinical validity of bromazepam in individual patients was evaluated considering e efficacy and side effects, benefit was resulted in 18 (80010; marked in 10(28.6%) and modest in 18 patients(51.4%).
These results suggest that bromazepam is a beneficial drug in treating psychoneurotic sAtoms associated with some cardiovascular diseased and help treat stress-related cardiovascularr diseases by reducing anxiety underlying them.
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